A story between PubMed IDs 12389004 (nicotinamide) and 11420111 (poly-ADP-ribose).

This story connects nicotinamide to PAR/PARP and is more interesting when the individual papers in the story are observed, especially in light of NAM lifespan extension. The focus of the paper with PubMed ID 16701870 is actually Nampt, the rate-limiting enzyme in the NAD salvage pathway. This enzyme also acts as a cytokine and is modulated by NF-kB activity, which is known to be dependent on PARP. Considering all these facts, one can build a hypothesis that PARP modulates Nampt.