<b>Pemivibart Structural Vulnerability Index (PSVI) - Global Spike Escape Haplotype Dataset (n=65,463)</b><i>Computational surveillance of SARS-CoV-2 escape potential against VYD2311, derived from 65,463 global sequences. Includes residue-level escape flags, PSVI score, and haplotype class.</i>

This dataset presents the Pemivibart Structural Vulnerability Index (<b>PSVI</b>), a computational metric quantifying global SARS-CoV-2 escape potential against the monoclonal antibody <b>VYD2311</b> (Pemivibart). Derived from <b>65,463</b> globally sampled Spike protein sequences, the <b>PSVI integrates structural epitope mapping </b>with genomic surveillance to identify high-risk haplotypes.The accompanying summary provides an overview of key findings:<b>PSVI Score Distribution</b>: The number of escape mutations per sequence.<b>Haplotype Risk Class</b>: Prevalence of sequences classified as None, LowRisk, Elevated, or HighRisk.<b>Escape Mutation Frequency</b>: Per-residue escape rates at the 9 critical sites (R346, K444, F456, N460, F486, S371, Y498, N501, Y505).<b>Top 10 High-Risk Constellations</b>: The most frequent multi-mutation escape haplotypes driving High Risk classification.This resource is intended for researchers and public health agencies to monitor the real-time evolution of Pemivibart resistance and inform therapeutic strategy. The underlying data enables further analysis of geographic, temporal, and lineage-specific trends.Study by: Tahir HB