Extrachromosomal Circular DNA Amplification Contributes to Gene Expression and Disease Relapse in Colorectal Cancer
收藏NIAID Data Ecosystem2026-05-10 收录
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https://www.ncbi.nlm.nih.gov/sra/SRP545444
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Extrachromosomal circular DNA (eccDNA) are circular DNA molecules originating from chromosomal DNA but existing independently. While large eccDNA (ecDNA) contributes to tumorigenesis, the role of smaller eccDNA (<100,000 base pairs) in cancer remains unclear. Our analysis of 25 colorectal cancer (CRC) tumors and adjacent non-tumorous tissues revealed that eccDNA is significantly more abundant in tumor tissues, correlating strongly with cancer relapse and chromosomal amplifications. Importantly,
创建时间：
2025-12-31
