Crystal structure of human folate receptor alpha in complex with novel antifolate AGF183
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Crystal structure of human folate receptor alpha in complex with novel antifolate AGF183 Descriptor: Folate receptor alpha, N-(4-{[2-(2-amino-4-oxo-4,7-dihydro-3H-pyrrolo[2,3-d]pyrimidin-6-yl)ethyl]amino}benzene-1-carbonyl)-L-glutamic acid Authors: Ke, J, Gu, X, Brunzelle, J.S, Xu, H.E, Melcher, K. Deposit date: 2016-03-25 Release date: 2016-08-10 Last modified: 2024-10-16 Method: X-RAY DIFFRACTION (3.6 Å) Cite: Tumor Targeting with Novel 6-Substituted Pyrrolo [2,3-d] Pyrimidine Antifolates with Heteroatom Bridge Substitutions via Cellular Uptake by Folate Receptor alpha and the Proton-Coupled Folate Transporter and Inhibition of de Novo Purine Nucleotide Biosynthesis. J.Med.Chem., 59, 2016
创建时间：
2016-03-25
