Gunnilactams A–C, Macrocyclic Tetralactams from the Mycelial Culture of the Entomogenous Fungus <i>Paecilomyces gunnii</i>
收藏NIAID Data Ecosystem2026-03-10 收录
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Three novel macrocyclic tetralactams, gunnilactam A (1), gunnilactam B (2), and gunnilactam C (3), were isolated from the submerged fermentation broth of Paecilomyces gunnii, an entomogenous fungus identified as the anamorph of Cordyceps gunnii. Their structures were determined using NMR data, HREIMS, and single-crystal X-ray crystallography. Gunnilactam A exhibited selective cytotoxic activity against human prostate cancer C42B cells with an IC50 value of 5.4 μM.
创建时间：
2017-05-31
