A Stat3-STING-IFN axis controls the metastatic spread of small cell lung cancer

To define the impact of STAT3-deletion on gene expresssion in primary and metastatic small cell lung cancer Gene expression was defined for cell lines derived from primary or liver metastases from independent mice by RNA-Seq Comparative gene expression profiling analysis of RNA-seq data for Rb1-/-:Trp53-/-:MYC (RPM) or Rb1-/-:Trp53-/-:MYC:STAT3-/- (RPMS) cells derived from small cell lung cancer from either lung or liver metastases.