Construction of Dispirocyclopentanebisoxindoles via Self-Domino Michael-Aldol Reactions of 3‑Phenacylideneoxindoles

A simple
protocol for the construction of novel dispirocyclopentanebisoxindoles
is accomplished by the base promoted domino reactions between two
molecules of 3-phenacylideneoxindoles with the participation of solvents,
alcohol, or other added nucleophiles such as amines or thiophenols.
Significantly, this domino reaction results in the complex dispiro
compounds with high yields and diastereoselectivity, which would allow
construction of dispirocyclopentanebisoxindole with four and five
diastereoisomeric centers using simple materials.