NGS processed VCFs, per-sample post-processed CSVs, and Maestro project files for the TYR / FANCD2 study

This archive contains 63 folders in total: 62 sample folders and 1 project/protein folder. Each of the 62 sample folders contains two files: a processed VCF file (*.vcf) — variant calls produced by the NGS pipeline (filtered and QC’ed). a post-processed CSV file (*.csv) — per-sample results after annotation, and preparation according to the manuscript methods. These CSV files are intended to be merged across the 62 samples to produce the consolidated table used for statistical testing. Key example filenames included: passed_filtered_without_Y_and_benign_AD_GT_matched_pgl.vcf(Example of the final VCF output from the NGS pipeline.) Franklin_Results_Without_Benign_LikelyBenign.csv(Example of a results table used for statistical analyses after adjustment. Note: check whether this is a single-sample or already-merged file in the archive; CSVs are generally per-sample and can be concatenated.) Project / protein folder contents (the single, separate folder): Project_TYR_AF.prj(Schrödinger Maestro project file — restores the project workspace.) proteinprep_TYR_AF/(Prepared protein structures for downstream analysis. All structure files are in .mae format.) sitemap_TYR_AF/(Sitemap outputs describing predicted active sites / pockets.)