Spatial transcriptome reveals disturbance of peri-infundibular immune infiltration in androgenetic alopecia

Several studies have suggested that in addition to androgen-sensitive dermal papilla cells, peri-infundibular immune infiltration is associated with the balding process in androgenetic alopecia (AGA). Nevertheless, investigations into the molecular signatures of this compartments are limited because none of the current techniques enable high-throughput profiling of specific pathological areas. Overall design: The spatial transcriptome technique was used to capture the transcriptome profiles of CD45+ peri-infundibular immune infiltration (PII) regions to identify molecular perturbations between PII from AGA patients (PII-A) and normal donors (PII-C)