Enhanced differentiation of Alzheimer's disease neural progenitor cells into vulnerable immature neurons

Alterations in neural cells preceding the onset of Alzheimer's disease (AD) have remained elusive. Using isogenic human induced pluripotent stem cells (hiPSCs) with an APPswe mutation, we find that APPswe neural progenitor cells (NPCs) exhibit early neuronal differentiation and remain immature, and increased ROS levels were necessary for this premature differentiation. APPswe neural cells showed heightened susceptibility to toxicity, highlighting their vulnerability in early AD stages. Overall design: To investigate transcriptomic alterations in NPC by APPswe or high levels of reactive oxygen species