Text S1 - Severe South American Ocular Toxoplasmosis Is Associated with Decreased Ifn-γ/Il-17a and Increased Il-6/Il-13 Intraocular Levels

Checklist S1. Strobe checklist for a cross sectional study, including 19 French and 23 Colombian cases of confirmed active ocular toxoplasmosis. Clinical, parasitological and immunological responses are compared and correlated to the infecting strains. Figure S1. Fundus examination in a patient with bilateral-extensive-multiple, central and peripheral, chorio-retinal scars (white circled lesions) in a Colombian patient suffering from a severe ocular toxoplasmosis; A : right eye; B : left eye. Table S1. Complete data of all clinical and laboratory characteristics. Mann and Whitney test followed by Bonferroni-Dunn's Multiple Comparison test was applied (P values<0.05 were considered statistically significant). Table S2. Intraocular cytokines, chemokines and growth factors in aqueous humor of Cataract Control patients from France (CT-CO) and Colombia (CT-FR) and from Ocular toxoplasmosis patients from France (OT-FR) and Colombia (OT-CO). Levels of these immune mediators are expressed as mean and standard deviation, median and range (min-max) in pg/mL. Statistical differences between CT and OT and between OT from France versus OT from Colombia were calculated using a Kruskal-Wallis test followed by Dunn's Multiple Comparison test. Significant differences between populations (P<0.05) were highlighted by tinting the spaces. Description of major general functions of cytokines and chemokines are issued from “Commins SP et al., J Allerg Clin Immunol, 2010; Banchereau J. et al., Nature Immunology, 2012”.
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