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ChIPseq and RNAseq analysis of T47D cells with/without silencing TRPS1/CHD4

NIAID Data Ecosystem2026-05-26 收录

乳腺癌转录抑制

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数据链接：

https://www.ncbi.nlm.nih.gov/sra/SRP145099 数据链接链接失效反馈

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资源简介：

We reported the transcriptional regulation function and mechanism of TRPS1-CHD4/NuRD. Overall design: Examination of transcription repression role of TRPS1 in breast cancer cells by ChIP and RNA-seq in duplicates using illumina hiseq2500.

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创建时间：

2019-02-23

细胞转分化

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MyoD is known to transdifferentiate fibroblasts into muscle-like cells. Despite phenotypic resemblance and expression of myogenic marker genes in transdifferentiated cells, our global gene expression

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Serine ADP-ribosylation marks nucleosomes for ALC1-dependent chromatin remodeling

ADP-核糖基化

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Serine ADP-ribosylation (ADPr) is a DNA damage-induced post-translational modification catalyzed by the PARP1/2:HPF1 complex. As the list of PARP1/2:HPF1 substrates continues to expand, there is a nee

NIAID Data Ecosystem70

The histone variant H2A.Z in yeast is almost exclusively incorporated into the +1 nucleosome in the direction of transcription

组蛋白变体定位

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To investigate the incorporation dynamics of histone variant H2A.Z, we determined its genomic localization at single nucleosome resolution, as well as the localization of its chromatin remodelers Swr1

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The TRIPLE PHD FINGERS proteins are required for SWI/SNF complex-mediated +1 nucleosome positioning and transcription start site selection in Arabidopsis [RNA-seq]. The TRIPLE PHD FINGERS proteins are required for SWI/SNF complex-mediated +1 nucleosome positioning and transcription start site selection in Arabidopsis [RNA-seq]

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RNA测序

In eukaryotes, DNA is associated with histones to form nucleosomes, the basic component of the chromatin. This structure presents a physical barrier for nuclear proteins to access DNA and, therefore,

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The chromatin remodelling factor ATRX suppresses R-loops in transcribed telomeric repeats

R-loop调控

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ATRX is a chromatin remodelling factor found at a wide range of tandemly repeated sequences including telomeres (TTAGGG)n. Acquired mutations in ATRX are found in nearly all tumours which maintain the

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ChIPseq and RNAseq analysis of T47D cells with/without silencing TRPS1/CHD4

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