Expression data of wild-type and perforin-knockout CAR-T cell. Expression data of wild-type and perforin-knockout CAR-T cell

Murine chimeric antigen receptor transduced T cells (CAR-T cells) deficient in perforin recapitulate hemophagocytic lymphohistiocytosis (HLH)-like toxicities occuring in human CAR-T recipients. We used microarray to describe gene expression profiles of wild-type and perforin-deficient CAR-T cells. Overall design: RNA was extracted from murine wild-type and perforin-deficient CD8+ CAR-T cells, before and after CAR-mediated in vitro activation of T cells with cognate-antigen-positive leukemia, followed by hybridization on Affymetrix array.