Supplementary Materials. Micronized purified flavonoid fraction in the treatment of hemorrhoidal disease.

Table
S1. List of studies
included in the systematic review.
Hemorrhoidal
disease (HD) is common in adults. Treatment is largely conservative, although
more invasive procedures may be required. Venoactive drugs such as micronized
purified flavonoid fraction (MPFF) are widely used, but a recent and
comprehensive review of supporting evidence is lacking. In acute HD, MPFF can
reduce HD symptoms such as bleeding, pain, anal discomfort, anal discharge,
and pruritus. In patients undergoing surgery, post-operative adjunct MPFF
consistently reduces pain, bleeding duration, and use of analgesia. MPFF
treatment is appropriate and effective both as a first-line conservative
treatment and as a post-operative adjunct treatment. MPFF reduces the
duration of hospital stay following surgery, facilitating a return to normal
activity and improving quality of life. MPFF may also prevent HD recurrence.