Data from: Genetic Architecture of Addiction-Relevant Behaviors in Outbred Sprague-Dawley Rats Reveals Loci for Anxiety-Like and Nociceptive Traits. In Abraham A. Palmer Lab Research Data Collection

This dataset supports the manuscript “Genetic Architecture of Addiction-Relevant Behaviors in Outbred Sprague-Dawley Rats Reveals Loci for Anxiety-Like and Nociceptive Traits.” The study examined common genetic variation associated with addiction-relevant behavioral traits in commercially outbred Charles River Sprague-Dawley rats.

The dataset includes raw behavioral phenotypes, processed phenotypes used for genome-wide association studies (GWAS), filtered genotype data, GWAS summary statistics for the manuscript traits, and a sensitivity-analysis phenotype file for tail flick latency excluding animals at the 15-second ceiling. Behavioral assays included locomotor response to a novel environment, elevated plus maze, and tail flick thermal nociception testing. Traits include total, lateral, and rearing locomotor scores; elevated plus maze open-arm time, open-arm entries, percent open-arm time, open-arm time ratio, distance traveled, velocity, and immobility; and tail flick latency.

The associated analyses estimated SNP heritability and performed GWAS using linear mixed models with leave-one-chromosome-out genomic relatedness matrices and permutation-derived genome-wide significance thresholds. Genotypes are aligned to the GRCr8 rat reference genome. Sequence Read Archive (SRA) data are available at https://www.ncbi.nlm.nih.gov/bioproject/PRJNA1460565.