Massively parallel engineering of persistent CAR-Ts [GEO_CLASH_Integration_off_targets]
收藏NIAID Data Ecosystem2026-03-14 收录
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资源简介：
To identify immune-related gene perturbations that enhance CAR-T cell persistence in in vitro and in vivo settings, we generated thousands of CAR-T variants using the CLASH platform and evaluated crRNA representation across time in in vitro and in vivo cancer models. First round PCR primers (CP-1) were designed to target unique regions of CAR vector. Second round PCR 3' primers (CP-2) were designed to targeting LHA.
创建时间：
2022-12-12
