Discovery of XL335, a Highly Potent, Selective and Orally-Active Agonist of the Farnesoid X Receptor (FXR)
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Discovery of XL335, a Highly Potent, Selective and Orally-Active Agonist of the Farnesoid X Receptor (FXR) Descriptor: 1-methylethyl 3-[(3,4-difluorophenyl)carbonyl]-1,1-dimethyl-1,2,3,6-tetrahydroazepino[4,5-b]indole-5-carboxylate, Bile acid receptor Authors: Foster, P.G, Stout, T.J. Deposit date: 2008-12-18 Release date: 2009-12-22 Last modified: 2024-02-21 Method: X-RAY DIFFRACTION (2 Å) Cite: Discovery of XL335 (WAY-362450), a highly potent, selective, and orally active agonist of the farnesoid X receptor (FXR). J.Med.Chem., 52, 2009
创建时间：
2008-12-18
