Androgen-independent prostate adenocarcinomas are responsible for about 6% of overall cancer deaths in men. We used DNA microarrays to identify genes related to the transition between androgen-depende
BackgroundMany men develop a rising PSA after initial therapy for prostate cancer. While some of these men will develop a local or metastatic recurrence that warrants further therapy, others will have
Androgen receptor (AR) plays an essential role in normal prostate development and prostate cancer (PCa) progression. To understand the role of AR at the single-cell level, we performed single-cell tra
Single-cell multiomics sequencing analysis of cells freshly dissociated from prostate tumors with independent replicates at different cancer progression stages (Figures 1B and S1D), which enabled the
