Polyploidy can drive rapid adaptation in yeast. Saccharomyces cerevisiae

Analysis of copy number variation in evolved haploid, diploid, tetraploid strains. Overall design: All experimental samples were compared to the same reference strain S288C. The samples include the progenitor strains for the haploid, diploid, and tetraploid evolution experiments, and single colony isolates (clones) from the evolving populations at given time points. Evolved clones were analyzed at generation 250 unless the name is followed by gen35, gen55 or gen500, in which case those generations were analyzed.