Enhanced Pathogenicity of Th17 cells Generated in the Absence of Transforming Growth Factor-β Signaling: ChIPSeq

ChEBI2010-08-31 更新2026-07-21 收录

Th17细胞调控

表观遗传学ChIPSeq分析

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https://www.ebi.ac.uk/biostudies/ArrayExpress/studies/E-GEOD-23681 数据链接链接失效反馈

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Enhanced Pathogenicity of Th17 cells Generated in the Absence of Transforming Growth Factor-β Signaling: ChIPSeq

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2010-08-31

Ikzf1 lactylation regulates CD4 T cell differentiation. Ikzf1 lactylation regulates CD4 T cell differentiation

Th17细胞调控

乳酸化修饰

Dysregulation of Th17 differentiation was implicated in multiple inflammatory and autoimmune diseases including autoimmune uveitis. In the current study, we have provided evidence indicating that lact

NIAID Data Ecosystem60

BET bromodomain inhibition suppresses TH17-mediated pathology. Mus musculus

Th17细胞调控

自身免疫疾病治疗

IL-17-producing T helper (TH17) cells have been selected through evolution for their ability to control fungal and bacterial infections. It is also firmly established that their aberrant generation an

NIAID Data Ecosystem50

Data_Sheet_4_Lnc-ITSN1-2, Derived From RNA Sequencing, Correlates With Increased Disease Risk, Activity and Promotes CD4+ T Cell Activation, Proliferation and Th1/Th17 Cell Differentiation by Serving as a ceRNA for IL-23R via Sponging miR-125a in Inflammatory Bowel Disease.zip

结肠炎机制

Th17细胞调控

Background: This study aimed to investigate long-non-coding RNA (lncRNA) expression profiles and the correlation of lnc-ITSN1-2 expression with disease risk, activity and inflammation, and its influen

NIAID Data Ecosystem30

Genome-wide binding of STAT3 and STAT5 under Th17 conditions (ChIP-Seq). Mus musculus

Th17细胞调控

ChIP-seq分析

Interleukin 2 (IL-2), a cytokine linked to human autoimmune diseases, limits IL-17 production. We show that deletion of Stat3 in T cells abrogates IL-17 production and attenuates autoimmunity associat

NIAID Data Ecosystem50

Transcription factor TCF1 binds Rorgt and orchestrates a regulatory network that determines homeostatic Th17 cell state [ATAC-seq]. Transcription factor TCF1 binds Rorgt and orchestrates a regulatory network that determines homeostatic Th17 cell state [ATAC-seq]

Th17细胞调控

染色质可及性分析

CD4+ T helper 17 (Th17) cells encompass a spectrum of cell states including homeostatic cells that maintain physiological functions such as barrier integrity and pathogenic cells that drive autoimmune

NIAID Data Ecosystem40

Enhanced Pathogenicity of Th17 cells Generated in the Absence of Transforming Growth Factor-β Signaling: ChIPSeq

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