SYNJ hydrolyze PI(4,5)P2 to PI(4)P
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Inositol-5-phosphatases like SYNJs and OCRL hydrolyze PI(4,5)P2 to PI(4)P. In the context of CME, this promotes the abortive turnover (disassembly) of some CCPs, contributes to the dynamin-mediated scission of the clathrin-coated vesicle neck, and promotes clathrin uncoating following scission (Guan et al, 2010; Cremona et al, 1999; Mani et al, 2007; Chang-Ileto et al, 2011; Antonescu et al, 2011; reviewed in McMahon and Boucrot, 2011; Daumke et al, 2014).
肌醇-5-磷酸酶类,如 SYNJs 和 OCRL,能够将 PI(4,5)P2 水解为 PI(4)P。在细胞膜出芽(CME)过程中,这一过程促进了某些 CCPs 的废弃性周转(拆解),并参与了由 dynamin 介导的网格蛋白包被囊泡颈部的切割,同时也在切割后促进了网格蛋白的脱包被(Guan 等,2010;Cremona 等,1999;Mani 等,2007;Chang-Ileto 等,2011;Antonescu 等,2011;参见 McMahon 和 Boucrot,2011;Daumke 等,2014 的综述)。
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