Glioblastoma (GBM) is the deadliest brain malignancy without effective treatments. Here, we report that epidermal growth factor receptor-targeted chimeric antigen receptor T cells (EGFR CAR-T) are eff

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De novo designed receptor transmembrane domains enhance CAR-T cytotoxicity and attenuate cytokine release

CAR-T细胞疗法

跨膜结构域

De novo designed receptor transmembrane domains enhance CAR-T cytotoxicity and attenuate cytokine release

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Supplementary Data S2 from Rational Protein Design Yields a CD20 CAR with Superior Antitumor Efficacy Compared with CD19 CAR

CAR-T细胞疗法

肿瘤免疫治疗

List of gene names and FPKM values from bulk RNA-seq on T cells harvested from tumor-bearing mice (Fig. 4A-D, F and Supplementary Fig. S7).

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Additional file 1 of Nonviral mcDNA-mediated bispecific CAR T cells kill tumor cells in an experimental mouse model of hepatocellular carcinoma

CAR-T细胞疗法

肝细胞癌模型

Additional file 1.

Figshare2024-02-28 更新30