Glia contribute to the neuropathology of Parkinson disease (PD), but how they react opposingly to be beneficial or detrimental under pathological conditions, like promoting or eliminating SNCA/α-syn (
Immune dysregulation is increasingly recognized as a key contributor to Parkinson's disease (PD) pathogenesis. While microglia are established central nervous system (CNS) immune regulators, the role
Screening of Brain-Infiltrating T Cells After Adoptive Transfer in a Parkinson's Disease Animal Model of Mitochondrial Autoimmunity Conclusion: Mitochondrial antigen-specific CD8+ T cells infiltrate
Duplication of the SNCA gene (SNCADupl), linked to elevated levels of alpha-synuclein (aSyn), is a genetic cause of Parkinson's disease (PD). Our prior work with human-induced pluripotent stem cell (h
Mutations in the parkin gene are currently thought to be the most common cause of recessive familial Parkinsonism. Parkin functions as an E3 ligase to regulate protein turnover, and its function in mi