The Effect of P85, F68 and P105 on the Apparent Permeability of [3H(G)]pentamidine (9 nM) MDR1-MDCK Cell Monolayers in the Apical to Basolateral Direction and the Basolateral to Apical Direction.

The percentage recovery of pentamidine is also shown. All the data has been corrected for extracellular space by subtracting [14C(U)]sucrose (5.5 μM) Papp values which ranged from 0.89 to 2.00 x 10−6 cm/s. Each value represents three replicates for each n and n = 3. n.d. = not determined as integrity of the barrier compromised.