Proteomics analysis of myocardial tissue from ischemia/reperfusion (I/R) pig model treated with cardiosphere-derived cells (CDCs)

Some studies report better outcomes in cell therapy for myocardial infarction (MI) with repeated administrations. We aimed to elucidate the potential differences in terms protein expression after one or three doses of cardiosphere-derived cells (CDCs) in a porcine MI model. CDCs were isolated from swine cardiac explants, cultured in CGM, and prepared for administration. Pigs surviving a 90-minute balloon occlusion of the mid-LAD were randomly allocated to receive vehicle (CON), one (D1) or three (D3) doses of 30x106 CDCs via the infarct-related coronary artery.