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Genetic instruments for Mendelian Randomization analyses of childhood and adult BMI

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DataCite Commons2022-06-20 更新2025-04-17 收录
下载链接:
https://figshare.manchester.ac.uk/articles/dataset/Genetic_instruments_for_Mendelian_Randomization_analyses_of_childhood_and_adult_BMI/19940642
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This file lists variants used as instrumental variables for the manuscript "Separating the effects of childhood and adult body size on inflammatory arthritis: a Mendelian randomisation study". <br> We selected independent (linkage disequilibrium threshold of r2&lt;0.001 using PLINK and a reference panel of 10,000 randomly selected Europeans from UK Biobank) genome-wide significant (p&lt;5x10-8) SNPs, resulting in 313 childhood and 580 adult body size instruments. For multivariable MR, we repeated LD clumping for the combined set of SNPs from both exposures.
提供机构:
University of Manchester
创建时间:
2022-05-31
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