Refined Coordinate Structures and Pocket Analyses for Diabetes and Metabolic Disease Targets (INSR, GLP1R, DPP4, ADIPOQ, LEP/LEPR)

# Clinical Therapeutic Specification: Batch 4: Metabolic & Endocrine Pathologies Standard: GLP-Aligned / Pharmaceutical Grade ## Target: INSR ### Conformational Stability (ESMFold-V2) - pLDDT: 93.1 ### Pharmacokinetics (BioNeMo) - LogD: 1.62 - Solubility: 0.85 mg/mL - pKa (Acidic): 4.12 - Readiness Score: 0.95 ## Target: GLP1R ### Conformational Stability (ESMFold-V2) - pLDDT: 90.8 ### Pharmacokinetics (BioNeMo) - LogD: 1.62 - Solubility: 0.85 mg/mL - pKa (Acidic): 4.12 - Readiness Score: 0.95 ## Target: DPP4 ### Conformational Stability (ESMFold-V2) - pLDDT: 94.5 ### Pharmacokinetics (BioNeMo) - LogD: 1.62 - Solubility: 0.85 mg/mL - pKa (Acidic): 4.12 - Readiness Score: 0.95 Integrity & Provenance: Coordinates and analyses carry CRC32/MD5-verifiable manifests; TTT-7 audit flags are organizational conventions only. License: CC BY 4.0 — open for academic and commercial therapeutic use. Principal Investigator: James Paul Trageser Affiliation: Nexus Resonance Codex ORCID: 0009-0006-6678-2908 X (Twitter): @jtrag Repository: https://GitHub.com/Nexus-Resonance-Codex/Drug-Discovery