Phosphorylation of CRMPs by Cdk5

Cdk5:p35 complex is associated with Plexin-A through the actived form of Fyn. CRMPs are the downstream substrates for Cdk5. Cdk5 phosphorylates serine 522 of CRMPs. Phosphorylation of CRMPs mediates the Sema3A induced growth cone collapse.<br>Collapsin response mediator proteins (CRMPs) are five homologous cytosolic phosphoproteins (CRMP1–5) involved in neuronal differentiation and axonal guidance. These members oligomerize and exist as tetramers.

Cdk5:p35复合物通过Fyn激活形式与Plexin-A相联系。CRMPs是Cdk5的下游底物。Cdk5磷酸化CRMPs的丝氨酸522位。CRMPs的磷酸化介导了Sema3A诱导的生长锥塌陷。萎缩反应介导蛋白（CRMPs）是五种同源的细胞质磷酸蛋白（CRMP1-5），参与神经元分化和轴突导向。这些成员形成寡聚体，并以四聚体的形式存在。