Survival data.

Legend: Unadjusted and adjusted hazard ratios (HR) and 95% Confidence Intervals (CI) for end-stage renal disease (ESRD) and death associated with 1 unit (µmol/L) change in homoarginine. (‡) Relative risks for ESRD adjusted for levels of kidney function and proteinuria; relative risks for death adjusted for levels of kidney function, proteinuria, age, smoking habit, previous cardiovascular disease and diabetes. All models were independent of biomarkers of inflammation (C-reactive protein, fibrinogen, serum albumin), homo-cysteine, hypertension, body mass index and serum lipids, ADMA and L-arginine). Statistically significant estimates are reported in bold. In fully adjusted models (last column in Table 4), we also forced PTH, phosphate, calcium, 25-hydroxy Vit. D and 1,25-hydroxy Vit. D as potential confounders.