Crystal structure of human PRKACA complexed with DS01080522

Crystal structure of human PRKACA complexed with DS01080522 Descriptor: 1-chloranyl-~{N}-[(~{S})-(3-chloranyl-4-cyano-phenyl)-[(2~{R},4~{S})-4-oxidanylpyrrolidin-2-yl]methyl]-7-methoxy-isoquinoline-6-carboxamide, ZINC ION, cAMP-dependent protein kinase catalytic subunit alpha Authors: Suzuki, M, Ubukata, O, Toyoda, A. Deposit date: 2022-06-08 Release date: 2022-09-28 Last modified: 2024-11-20 Method: X-RAY DIFFRACTION (2.3 Å) Cite: Novel protein kinase cAMP-Activated Catalytic Subunit Alpha (PRKACA) inhibitor shows anti-tumor activity in a fibrolamellar hepatocellular carcinoma model. Biochem.Biophys.Res.Commun., 621, 2022