An Immunologic Approach to the Conformational Equilibria of Polypeptides An Immunologic Approach to the Conformational Equilibria of Polypeptides

Contributor(s): Anfinsen, Christian B. (Christian Boehmer), 1916-1995 Sachs, David H. (David Howard), 1942- Schechter, Alan N. Proceedings of the National Academy of Sciences of the United States of America Eastlake, Ann Publication: National Academy Press (U.S.), December 1972 Language(s): English Format: Text Subject(s): Antigen-Antibody Reactions Protein Conformation Antibody Specificity Epitopes Genre(s): Archival Materials Articles Abstract: Certain antibodies are particularly well-suited for the study of the conformational equilibria of polypeptide fragments of nuclease in solution. Here, Anfinsen, Schechter, Sachs, and Eastlake hypothesized that such fragments actually existed in solution in conformational equilibrium, components of which were sufficiently similar to the native conformation that antibodies directed to the native molecule could bind. They were able to validate this hypothesis by using synthetic polypeptide fragments, which were already known to induce folding of complimentary fragments. Copyright: This item may be under copyright protection; contact the copyright owner for permission before re-use. Extent: 5 pages NLM Unique ID: 101584571X176 (See in Profiles in Science) Profiles in Science ID: KKBBLL Permanent Link: http://resource.nlm.nih.gov/101584571X176 Archival Collection: The Christian B. Anfinsen Papers (Profiles in Science)