Binding and neutralization titers post-vaccination against the VOCs.

(A) Paired binding titers to wild-type and variants of concern (VOCs) S protein (BAU/ml) of 1:100,000 diluted sera collected post initial vaccination series for the four vaccination groups (upper plot). The lower cut-off for binding was set at an 30 BAU/ml (grey shading). Mean and standard error of the mean (SEM) for the fold reductions in binding titers against the VOCs in comparison to wild-type are shown (lower plot). (B) Mean ± SEM fold reductions in neutralization half-maximal inhibitory concentration (IC50) titers against the VOCs pseudoviruses in comparison to neutralization IC50 titers against D614G pseudovirus. (EMF)