Gene expression changes and DNA damage after ex vivo exposure of peripheral blood cells to variable CT photon spectra. Gene expression changes and DNA damage after ex vivo exposure of peripheral blood cells to variable CT photon spectra

In this study, we display traceable impact of energetically-varying CT irradiation on gene regulation with common upregulation of five radiation-responsive genes after single-energy (80 kV or 150kV) and dual-energy CT (80kV + 150kV) exposure. Furthermore, no evdidence for an elevated radiobiological effectiveness in respect to transcriptional impact of low energy photons emitted during dual-energy CT was found. Overall design: Analysis of RNA-Seq changes after single-energy CT- and dual-energy CT-exposure in peripheral human blood cells.