Crystal structure of human KDM4A in complex with compound 18a
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Crystal structure of human KDM4A in complex with compound 18a Descriptor: 8-[4-[2-[4-[3-(trifluoromethyl)phenyl]piperidin-1-yl]ethyl]pyrazol-1-yl]-3~{H}-pyrido[3,4-d]pyrimidin-4-one, CHLORIDE ION, DIMETHYL SULFOXIDE, ... Authors: Le Bihan, Y.V, van Montfort, R.L.M. Deposit date: 2018-07-23 Release date: 2019-06-12 Last modified: 2024-01-17 Method: X-RAY DIFFRACTION (2.25 Å) Cite: C8-substituted pyrido[3,4-d]pyrimidin-4(3H)-ones: Studies towards the identification of potent, cell penetrant Jumonji C domain containing histone lysine demethylase 4 subfamily (KDM4) inhibitors, compound profiling in cell-based target engagement assays. Eur.J.Med.Chem., 177, 2019
创建时间：
2018-07-23
