Downregulation of NSRP1 confers CDK4/6i resistance in breast cancer via activation of the IFN signaling pathway. Downregulation of NSRP1 confers CDK4/6i resistance in breast cancer via activation of the IFN signaling pathway

Via analyzing the expression matrix of palbociclib-sensitive and palbociclib-resistant tumors from patients with breast cancer, it was revealed that NSRP1 is associated with CDK4/6i resistance. Therefore, RNA Sequencing is performed for MCF7 cells transfected with ctr or NSRP1 siRNA to study the molecular mechanism of NSRP1 in mediating CDK4/6i resistance in breast cancer cells. Overall design: We transfected MCF7 cells with NSRP1 siRNAs or control siRNA.