Transcriptomic analysis reveals rescue of dysregulated genes in SBMA muscle upon silencing of AR co-factors
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https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE193539
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Purpose: The goal of this study is to evaluate the rescue of SBMA phenotype upon modulation of AR co-factors expression Results: NGS analysis of the transcriptome of quadriceps isolated from SBMA mice upon treatment reveal the rescue (partial or total) of assemblies of genes involved in SBMA pathogenesis Conclusion: targeting overexpressed AR co-regulators is a new therapeutic approach for SBMA to attenuate the toxic GOF without exacerbating AR LOF RNA from quadriceps of wt and AR100Q (mouse model of SBMA) +/- silencing of AR co-factors
创建时间：
2023-02-07
