NMuMG cell response to TGF-beta and TGF-beta +2APB treatments
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https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE98596
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Recent studies demonstrate that Ca2+ signaling has an important role in EMT. Use of Ca2+ blockers such as 2APB can inhibit cell migration induced by TGF-β. Interestingly, we see an unexpected increase in Snail expression upon Ca2+ blocker treatment of both MCF10A and NMuMG cells; this increase is not observed with 2APB treatment alone. Therefore, we believe that 2APB plays a synergistic role with TGF-β in Snail induction. We propose to investigate the gene networks that change following 2APB +TGF-β treatment. mRNA profiles of NMuMG cells treated with TGFbeta, TGFBeta and 2APB, and DMSO control were generated using deep sequencing, in duplicate
创建时间：
2019-03-19
