Impact of vaccination on antibiotic resistance and population structure of Salmonella Typhi in Harare, Zimbabwe. Salmonella enterica subsp. enterica serovar Typhi

Typhoid fever, caused by the bacteria Salmonella enterica serotype Typhi, results in 26 million infections each year. The emergence and global spread of multi-drug resistant (MDR) and fluoroquinolone resistant S. Typhi is a major concern, as it compromises treatment options. Vaccines are increasingly viewed as a key tool in the fight against AMR, both by preventing infection with a resistant pathogen (direct) or reducing the need for antimicrobial treatment (indirect).In this project, our key goal is to investigate the impact of the 2019 typhoid conjugate vaccine campaign in Zimbabwe on circulating S. Typhi population structure and antibiotic resistance.