Deep enzymology data related to Adam et al.: DNA sequence-dependent activity ...

B2FIND2026-04-29 收录

DNA甲基化动力学

酶序列特异性分析

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Methylation of random flank substrates: Libraries of double stranded DNA substrates with unmethylated or hemimethylated CpG sites in randomized sequence context were methlyated...

DNA methylation analysis and expression profiling during murine embryogenesis and in embryos deficient for DNMT3A or DNMT3B

发育表观遗传学

DNA甲基化动力学

We quantified the targets and kinetics of DNA methylation acquisition in mouse embryos, and determined the contribution of the de novo methyltransferases DNMT3A and DNMT3B to this process. We provide

NIAID Data Ecosystem50

De novo DNA methyltransferases DNMT3A and DNMT3B are essential of global DNA methylation maintenance [RNA-Seq]. Mus musculus

DNA甲基化动力学

造血干细胞表观遗传重编程

DNA methylation is the net result of deposition by DNA methyltransferases (DNMT1, 3A and 3B) and removal by the Ten-Eleven Translocation 1-3 (TET1-3) family of proteins and/or passive loss by replicat

NIAID Data Ecosystem40

RNase H Sequence Preferences

酶序列特异性分析

反义治疗机制研究

A massive parallel-sequencing-based method for determining RNase H sequence preferences was developed and applied on human RNase H1, E. coli RNase HI and the HIV-1 reverse transcriptase. Obtained sequ

NIAID Data Ecosystem20

Imprecise DNMT1 activity coupled with neighbor-guided correction enables robust yet flexible epigenetic inheritance. Imprecise DNMT1 activity coupled with neighbor-guided correction enables robust yet flexible epigenetic inheritance

DNA甲基化动力学

表观遗传稳定性

The epigenome, including DNA methylation, is stably propagated during mitotic division. However, single-cell clonal expansion produces heterogeneous methylomes, raising the question of how the DNA met

NIAID Data Ecosystem50

DNA Methylation Density Influences the Stability of an Epigenetic Imprint and Dnmt3a/b-Independent De Novo Methylation

DNA甲基化动力学

表观遗传酶学

DNA methylation plays an important role in transcriptional repression. To gain insight into the dynamics of demethylation and de novo methylation, we introduced a proviral reporter, premethylated at d

PubMed Central30

Deep enzymology data related to Adam et al.: DNA sequence-dependent activity ...

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