The P valve of variable factors on PK and BP change parameters in the corrected models.

Data were shown as mean±SD; *P<0.05; **P<0.01. ORM1, orosomucoid 1; ABCC2, ATP-binding cassette, sub-family C, member 2; ABCG2, ATP-binding cassette, sub-family G, member 2; ABCB1, ATP-binding cassette, sub-family B, member 1; SLCO1B3, solute carrier organic anion transporter family, member 1B3; AUC(0–∞) the area under the plasma concentration-time curve(AUC) from 0 to ∞; Cmax, the peak concentration in plasma; CL/F, clearance; T1/2, elimination half-life; Tmax, the time to Cmax; SBP, systolic blood pressure; DBP, diastolic blood pressure.