Stereoselective and Efficient Total Synthesis of Optically Active Tetrodotoxin from d-Glucose
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A stereoselective and efficient total synthesis of optically active tetrodotoxin (TTX) is described. A polyfunctionalized key cyclitol compound containing branched-chains for the synthesis of TTX was prepared from d-glucose employing the Henry reaction (Nitro aldol reaction) as the key transformation. Stereoselective construction of the α-azido-aldehyde branched-chain was achieved via the key spiro α-chloroepoxide intermediate.
创建时间：
2016-06-03
