five

Homo sapiens isolate:A375 Raw sequence reads

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NIAID Data Ecosystem2026-03-10 收录
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https://www.ncbi.nlm.nih.gov/sra/SRP072285
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The translation initiation factors eIF4A1 and eIF4E are members of the eIF4F cap-binding complex that is frequently upregulated in cancers. There are ongoing efforts to develop eIF4F inhibitors as cancer therapies, but the molecular mechanisms of eIF4F-driven tumor progression remain unclear. To investigate the molecular basis of these phenotypes, we performed an integrative proteomic and transcriptomic analysis in A375 melanoma cells treated with siRNAs against eIF4A1 or eIF4E for 72 hours.
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2017-11-21
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