Disease scoring when the causal SNP is not typed or imputed.

We list the average maximum statistic and the percentage of times it attains genome wide significance (defined as P<5e-08 for all scores except ADM, P<1e-05 for ADM) for each of the case-control scores obtained in a region of 40 SNPs centered around the 100,000 simulated causal SNPs with R = 1.5. The results obtained when the score at the simulated causal SNP was removed from the computation of the maximum are denoted in bold. The MIX score outperforms the other scores both when the causal is present or unobserved in the data.