Natural and pharmacological regulation of telomerase
收藏PubMed Central2002-02-15 更新2026-05-16 收录
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https://pmc.ncbi.nlm.nih.gov/articles/PMC100331/
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资源简介：
The extremities of eukaryotic chromosomes are called telomeres. They have a structure unlike the bulk of the chromosome, which allows the cell DNA repair machinery to distinguish them from ‘broken’ DNA ends. But these specialised structures present a problem when it comes to replicating the DNA. Indeed, telomeric DNA progressively erodes with each round of cell division in cells that do not express telomerase, a specialised reverse transcriptase necessary to fully duplicate the telomeric DNA. Telomerase is expressed in tumour cells but not in most somatic cells and thus telomeres and telomerase may be proposed as attractive targets for the discovery of new anticancer agents.
提供机构：
Oxford University Press
创建时间：
2002-02-15
