A conserved long noncoding RNA, GAPLINC, modulates the immune response during endotoxic shock

GAPLINC is a conserved long noncoding RNA that we find to be highly expressed in macrophages. Inflammatory activation of macrophages results in a decrease in GAPLINC expression, and GAPLINC knockout results in an enhanced expression of inflammatory genes at baseline. To gain insights into the molecular mechanism of GAPLINC, we generated RNA-seq libraries from wild type and GAPLINC-deficient BMDMs untreated and treated with LPS. Transcriptome analysis of undifferentiated bone-marrow-derived macrophages (BMDMs) of wild-type and GAPLINC-deficient mice