Effect of glucokinase regulatory protein (GCKR)-rs1260326 on gene expression in human liver organoids

To investigate the functional difference between rs1260326:C>T in the regulation of lipogenesis in the liver, we established human induced pluripotent stem cell lines from GCKR CC and GCKR TT variants. Overall design: We then performed gene expression profiling analysis using data obtained from RNA-seq of human liver organoids (HLOs) generated from 5 different cell lines of which 2 are GCKR TT variants and 3 from GCKR CC variants Comparative gene expression profiling analysis of RNA-seq data for human liver organoids generated from GCKR TT and CC cell lines.