N-acetylaspartylglutamate synthase A ligates NAA, L-Glu forming NAAG

N-Acetylaspartylglutamate (NAAG) is found at high concentrations in the vertebrate nervous system. It is an agonist of group II metabotropic glutamate receptors. A number of other functions have been proposed for NAAG, including a role as a non-excitotoxic transport form of glutamate and a molecular water pump (Lodder-Gadaczek et al. 2011, Neale et al. 2011).

NAAG is synthesized by N-acetylaspartylglutamate synthase A (RIMKLA, NAAG synthetase A) and Beta-citrylglutamate synthase B (RIMKLB, NAAG synthetase B), which more efficiently catalyzes the synthesis of beta-citryl-L-glutamate (Collard et al. 2010, Lodder-Gadaczek et al. 2011).

N-乙酰天冬氨酰谷氨酸（NAAG）在脊椎动物神经系统中的浓度较高。它是II型代谢型谷氨酸受体的激动剂。对于NAAG的多种功能已被提出，包括作为非兴奋毒性谷氨酸转运形式和分子水泵的作用（Lodder-Gadaczek 等人，2011年，Neale 等人，2011年）。NAAG由N-乙酰天冬氨酰谷氨酸合酶A（RIMKLA，NAAG合酶A）和β-香豆酰谷氨酸合酶B（RIMKLB，NAAG合酶B）合成，后者更有效地催化β-香豆酰-L-谷氨酸的合成（Collard 等人，2010年，Lodder-Gadaczek 等人，2011年）。