Apolipoprotein ε4 (APOE)4 is a strong risk factor for the development of Alzheimer’s disease (AD) and aberrant sphingolipid levels have been implicated in AD. We tested the hypothesis that the APOE4 g

NIAID Data Ecosystem30

Additional file 1 of Lipidomics profiling reveals distinct patterns of plasma sphingolipid alterations in Alzheimer’s disease and vascular dementia

阿尔茨海默病脂质组学

痴呆生物标志物

Additional file 1: Supplementary Table S1. Diagnostic criteria of clinical subgroups for this study. Supplementary Table S2. Summary of Neuropsychological Battery and Component Tests. Supplementary Ta

NIAID Data Ecosystem20

Lipidomic Network Analysis Reveals Amyloid-β-Induced Lysosomal Lipid Accumulation in the Cortex and Hippocampus of 5xFAD Mice

阿尔茨海默病脂质组学

溶酶体代谢

The 5xFAD mouse model serves as a valuable experimental system for investigating Alzheimer’s disease (AD), specifically amyloid-beta (Aβ)-induced AD pathology. In this study, we explored temporal, reg

Figshare2025-06-24 更新50

Pharmacokinetics Database

药代动力学数据

药物研发建模

PK-DB an open database for pharmacokinetics information from clinical trials as well as pre-clinical research. The focus of PK-DB is to provide high-quality pharmacokinetics data enriched with the req

知名数据库20

Untargeted Lipidomics of AD-like mouse brains

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