Oxygen consumption rate (OCR) and extracellular acidification rate (ECAR) in lymphoblasts from ALS patients with mutant SOD1 (mutSOD1) and unknown mutation (undSOD1).

Oxygen consumption rate (OCR) and extracellular acidification rate (ECAR) parameters in lymphoblasts from ALS patients with mutant SOD1 (mutSOD1) and unknown mutation (undSOD1). Cells were plated at density 160,000 cells/well, as described in Materials and Methods. Mitochondrial Stress Test featuring OCR- and ECAR-associated parameters were assessed with the Seahorse XFe96 Extracellular Flux Analyzer. OCR and ECAR parameters, as well as energy maps showing the metabolic potential of cells. Data were plotted for all cohorts (pool), C1-Female 46 years old, C2- Male 46 years old and C3-Male 26/27 years old. OCR parameters and ECAR evaluated.