MYDGF Governs Endothelial Homeostasis in Hypertension

Myeloid-derived growth factor (MYDGF) demonstrates well-established cardioprotective properties. However, its endothelial-specific functions and potential therapeutic applications in hypertension remain largely unexplored. Through comparative RNA sequencing analysis of Ang II-treated endothelial cells with versus without MYDGF overexpression, we identified genes associated with endothelial functional modulation. Overall design: The gene expression of 5 samples from 48 h Ang II induced AD-MYDGF endothelial cell line was compared to 5 samples from 48 h Ang II induced AD-NC samples by RNA sequencing.